What's happening in the group.
Papers, people, seminars, and the occasional piece of equipment that finally works.
Protein & Cell | O-GlcNAc clusters regulate transcriptional condensates
In collaboration with Prof. Jun Liu's team, we report that O-GlcNAc clusters within disordered regions of transcriptional regulators control the material properties of …
Silan Liu: Breaking the 'sweet armour' — The SMART Choice
Postdoctoral fellow Silan Liu shares the story behind her work on strategies that detect and manipulate cell-surface glycans.
Wang Na awarded an excellent poster prize at the 35th CCS Annual Meeting
Wang Na, our jointly-supervised PhD student, received an excellent poster award at the 19th session of the 35th Annual Meeting of the Chinese Chemical Society.
Nat Commun | Unlocking a non-catalytic function of OGT for targeted stress-granule control
Our Nature Communications paper reveals a non-catalytic function of OGT that enables targeted regulation of stress granules.
Glycosylated nanobody-engineered cellular vesicles for cancer immunotherapy
In collaboration with Prof. Lang Rao's team, we report engineered cellular vesicles displaying glycosylated nanobodies as a new platform for cancer immunotherapy.
A semisynthesis platform for didemnin-based drugs
In collaboration with Prof. Xiaoyu Tang's group, we report a semisynthesis platform that supports efficient production and functional exploration of didemnin-based drugs.
Sweet harmony
A year-end reflection from the group — Sweet harmony.
NCB | Glycosylation regulates YTHDF1/3 translation-promoting function and phase separation
Our Nature Cell Biology paper with Profs. Lin Shixian and He Chuan reveals that glycosylation controls YTHDF1/3 translation-promoting activity and phase-separation behaviour.
O-GlcNAc regulates YTHDF1 and YTHDF3 activity
Nature Cell Biology highlights our collaborative work on glycosylation regulation of YTHDF1/3.
Young Chemists Forum on Chemical Immunology & SZBL Chemical Biology Symposium
The Young Chemists Forum on Chemical Immunology and the SZBL Chemical Biology Symposium were successfully held.
Profile | Yun Ge: truth-seeking research, breakthroughs in chemical biology
PI Yun Ge shares her research journey and reflections on the chemical-biology field in a recent interview.
Five SZBL women scientists and teams honoured with nine awards
Five women scientists and their teams at the Shenzhen Bay Laboratory received nine honours in total, including PI Yun Ge.
Cutting sugar loose
Nat. Chem. Biol. highlights our ACS Chem. Biol. paper on small-molecule-activated O-GlcNAcase.
ACS Chem. Biol. | A small-molecule-activated O-GlcNAcase for live-cell O-GlcNAc removal
Our ACS Chem. Biol. paper reports a small-molecule-activated O-GlcNAcase that enables spatiotemporal removal of O-GlcNAc in live cells.
Yun Ge: deliberate accumulation and serendipitous branches — a research journey
PI Yun Ge reflects on her research journey — from undergraduate to PhD, postdoc, and independent PI — in a recent essay.
First SZBL & PKUSZ joint symposium on chemistry-biology interface
The first joint symposium between the Shenzhen Bay Laboratory (SZBL) and Peking University Shenzhen Graduate School (PKUSZ) was successfully held.
New tool to dissect the "undruggable"
Our small-molecule-activated O-GlcNAcase is reported as a new tool to dissect previously "undruggable" targets.
Nat Chem Biol | A protein-selective O-GlcNAc eraser for living cells
Our Nature Chemical Biology paper reports the first protein-selective O-GlcNAc eraser for functional dissection in living cells.
New labeling method can reveal cell-cell interactions
Our JACS paper reports an enzyme-mediated proximity labelling method for detecting cell-cell interactions.
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