Our Nature Chemical Biology paper reports the first protein-selective O-GlcNAc eraser for functional dissection in living cells.
Our paper “Target protein deglycosylation in living cells by a nanobody-fused split O-GlcNAcase” is published in Nature Chemical Biology. The work introduces the first protein-selective glycosylation eraser, enabling precise functional dissection of O-GlcNAcylation on a chosen target.
See doi: 10.1038/s41589-021-00757-y. Original write-up: WeChat.
In collaboration with Prof. Jun Liu's team, we report that O-GlcNAc clusters within disordered regions of transcriptional regulators control the material properties of …
Postdoctoral fellow Silan Liu shares the story behind her work on strategies that detect and manipulate cell-surface glycans.