Seeberger, P. H.; Ge, Y.; Szymanski, C. M.; Kolarich, D.; Thaysen-Andersen, M.; Packer, N. H.; Fadda, E.; Davis, B.; Nishihara, S.; Rabinovich, G. A.; Kwong, P. D.; Strasser, R.

PerspectiveGlycobiology

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Angew. Chem. Int. Ed. 2024, 63(12), e202318784 · DOI: 10.1002/anie.202318784

A Semisynthesis Platform for the Efficient Production and Exploration of Didemnin-Based Drugs

Zhang, H.#; Li, X.#; Hui, Z.; Huang, S.; Cai, M.; Shi, W.; Lin, Y.; Shen, J.; Sui, M.; Lai, Q.; Shao, Z.; Dou, J.; Luo, X.; Ge, Y.*; Tang, X.*

Translational applicationsSemisynthesisDidemninDrug discovery

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2023

Nat. Cell Biol. 2023, 25, 1676–1690 · DOI: 10.1038/s41556-023-01258-X

O-GlcNAcylation determines the biological function of YTHDF proteins

Chen, Y.#; Wan, R.#; Zou, Z.#; Lao, L.; Shao, G.; Zheng, Y.; Tang, L.; Yuan, Y.; Ge, Y.*; He, C.; Lin, S.*

Functional decodingO-GlcNAcylationYTHDFPhase separationTranslation

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CCS Chem. 2023, 5 (4), 802–813 · DOI: 10.31635/ccschem.023.202202593

Proximity Chemistry in Living Systems

Liu, Y.#; Ge, Y.#; Zeng, R.#; Ngai, W. S.; Fan, X.*; Chen, P. R.*

Precise glycan editingProximity chemistryEnzyme labellingReview

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ACS Chem. Biol. 2023, 18 (1), 193–201 · DOI: 10.1021/acschembio.2c00894

Small Molecule-Activated O-GlcNAcase for Spatiotemporal Removal of O-GlcNAc in Live Cells

Ge, Y.*; Lu, H.; Yang, B.; Woo, C. M.*

Precise glycan editingO-GlcNAcaseSmall-molecule activationLive cells

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2022

ACS Chem. Biol. 2022, 17 (5), 1111–1121 · DOI: 10.1021/acschembio.1c00987

Writing and Erasing O-GlcNAc on Casein Kinase 2 Alpha Alters the Phosphoproteome

Schwein, P. A.; Ge, Y.; Yang, B.; D'Souza, A. K.; Mody, A.; Shen, D.; Woo, C. M.*

Precise glycan editingO-GlcNAcCasein kinase 2PhosphoproteomePrior to SZBL

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2021

Biochem. Soc. Trans. 2021, 49 (6), 2891–2901 · DOI: 10.1042/BST20210865

Writing and erasing O-GlcNAc from target proteins in cells

Ge, Y.; Woo, C. M.*

Precise glycan editingO-GlcNAcChemical biologyReviewPrior to SZBL

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Curr. Protoc. 2021, 1 (5), e117 · DOI: 10.1002/cpz1.117

O-GlcNAc engineering on a target protein in cells with nanobody-OGT and -OGA

Ramirez, D. H.; Ge, Y.; Woo, C. M.*

Precise glycan editingProtocolO-GlcNAcNanobodyPrior to SZBL

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Nat. Chem. Biol. 2021, 17 (5), 593–600 · DOI: 10.1038/s41589-021-00757-y

Target protein deglycosylation in living cells by a nanobody-fused split O-GlcNAcase

Ge, Y.; Ramirez, D. H.; Yang, B.; D'Souza, A. K.; Aonbangkhen, C.; Wong, S.; Woo, C. M.*

Precise glycan editingNanobodyO-GlcNAcaseDeglycosylationPrior to SZBL

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2019

J. Am. Chem. Soc. 2019, 141 (5), 1833–1837 · DOI: 10.1021/jacs.8b10286

Enzyme-mediated intercellular proximity labeling for detecting cell-cell interactions

Ge, Y.#; Chen, L.#; Liu, S.; Zhao, J.; Zhang, H.; Chen, P. R.*

Precise glycan editingProximity labellingCell–cell interactionEnzyme-mediated labellingPrior to SZBL

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ACS Cent. Sci. 2019, 5 (1), 145–152 · DOI: 10.1021/acscentsci.8b00751

Bioorthogonal engineering of bacterial effectors for spatial-temporal modulation of cell signaling

Zhao, J.; Liu, Y.; Lin, F.; Wang, W.; Yang, S.; Ge, Y.; Chen, P. R.*

Precise glycan editingBioorthogonalBacterial effectorsCell signallingPrior to SZBL

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2018

Biochemistry 2018, 57 (4), 446–450 · DOI: 10.1021/acs.biochem.7b01017

Genetically encoded chemical decaging in living bacteria

Liu, L.; Liu, Y.; Zhang, G.; Ge, Y.; Fan, X.; Lin, F.; Wang, J.; Zheng, H.; Xie, X.; Zeng, X.; Chen, P. R.*

Precise glycan editingBioorthogonalDecagingBacteriaPrior to SZBL

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2017

Angew. Chem. Int. Ed. 2017, 56 (46), 14521–14525 · DOI: 10.1002/anie.201708151

Quantitative and comparative profiling of protease substrates through a genetically encoded multifunctional photocrosslinker

He, D.#; Xie, X.#; Yang, F.; Zhang, H.; Su, H.; Ge, Y.; Song, H.; Chen, P. R.*

Precise glycan editingPhotocrosslinkerProtease substratesActivity-based profilingPrior to SZBL

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2016

Chem. Sci. 2016, 7 (12), 7055–7060 · DOI: 10.1039/C6SC02615J

A genetically encoded multifunctional unnatural amino acid for versatile protein manipulations in living cells

Ge, Y.#; Fan, X.#; Chen, P. R.*

Precise glycan editingUnnatural amino acidGenetic code expansionBioorthogonalPrior to SZBL

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Angew. Chem. Int. Ed. 2016, 55 (45), 14046–14050 · DOI: 10.1002/anie.201608009

Optimized tetrazine derivatives for rapid bioorthogonal decaging in living cells

Fan, X.; Ge, Y.; Lin, F.; Yang, Y.; Zhang, G.; Ngai, W. S.; Lin, Z.; Zheng, S.; Wang, J.; Zhao, J.; Li, J.; Chen, P. R.*

Precise glycan editingTetrazineBioorthogonal decagingIEDDAPrior to SZBL

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ACS Cent. Sci. 2016, 2 (5), 325–331 · DOI: 10.1021/acscentsci.6b00024

Bioorthogonal chemical activation of kinases in living systems

Zhang, G.#; Li, J.#; Xie, R.; Fan, X.; Liu, Y.; Zheng, S.; Ge, Y.; Chen, P. R.*

Precise glycan editingBioorthogonalKinase activationCaged ATPPrior to SZBL

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2014

Chem. Commun. (Camb.) 2014, 50 (38), 4891–4894 · DOI: 10.1039/C4CC01528B

A diazirine-based photoaffinity probe for facile and efficient aptamer-protein covalent conjugation

Zhang, H.; Song, Y.; Zou, Y.; Ge, Y.; An, Y.; Ma, Y.; Zhu, Z.; Yang, C. J.*

AptamerPhotoaffinityDiazirinePrior to SZBL

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2012

J. Am. Chem. Soc. 2012, 134 (46), 18908–18911 · DOI: 10.1021/ja3082439

L-DNA molecular beacon: a safe, stable, and accurate intracellular nano-thermometer for temperature sensing in living cells

Ke, G.; Wang, C.; Ge, Y.; Zheng, N.; Zhu, Z.; Yang, C. J.*

Molecular beaconL-DNAIntracellular thermometryPrior to SZBL

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Showing 23 publications. View all on Google Scholar →